Kiara Advani has starred opposite Mahesh Babu in the movie "Bharat Ane Nenu" (2018). She played the role of Vasumathi in this Telugu political drama film directed by Koratala Siva.
Sonali Bendre has starred opposite Mahesh Babu in the movie "Murari" (2001). She played the role of Vasundhara in this Telugu romantic drama film directed by Krishna Vamsi.
Namrata Shirodkar is actually Mahesh Babu's wife. She has appeared in the movie "Vamsi" (2000) alongside Mahesh Babu. She played the role of Nandini in this Telugu action film directed by B. Gopal.
Ameesha Patel has Starred with Mahesh Babu in the film Naani (2004). She played the role of Priya in the Sci-fi drama. Priya is the love interest of Naani who is a child turned into a 28-year-old man by a scientist.
Amrita Rao starred with Mahesh Babu in the film Athidhi (2007). She plays the role of Amrita, who is the daughter of Athidhi's adopted parents who are murdered by a teenager and Athidhi is arrested for the crime. 13 years later he comes back for revenge.
Kriti Sanon worked with Mahesh Babu in the movie "1: Nenokkadine" (2014). She played the role of Sameera in this Telugu psychological thriller film directed by Sukumar.